Search found 487 matches

by Joe Ham
Sun 12 Apr 2009 20:17
Forum: Published Studies
Topic: In Vitro vs In Vivo Research / Testing
Replies: 17
Views: 2638

Re: In Vitro vs In Vivo Research / Testing

Infect Immun. 1988 August ; 56(8): 1831-1836 Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation. http://iai.asm.org/cgi/content/abstract/56/8/1831 http://iai.asm.org/cgi/reprint/56/8/1831.pdf T G Schwan, W Burgdorfer a...
by Joe Ham
Fri 10 Apr 2009 20:15
Forum: Medical Topics
Topic: Do Medications Really Expire?
Replies: 10
Views: 3418

Re: Do Medications Really Expire?

CYA? (the pharmacy, I mean) Yeah, maybe. He implied that it was a regulation that was implemented because the pharmacy had no control over how the customer would handle the drug. Stored on a window sill?, top of the fridge?, dashboard of a car? It may be a state regulation, maybe national, I don't ...
by Joe Ham
Fri 10 Apr 2009 19:24
Forum: Medical Topics
Topic: Do Medications Really Expire?
Replies: 10
Views: 3418

Re: Do Medications Really Expire?

From the link: A contested example of a rare exception is a case of renal tubular damage purportedly caused by expired tetracycline (reported by G. W. Frimpter and colleagues in JAMA, 1963;184:111). This outcome (disputed by other scientists) was supposedly caused by a chemical transformation of the...
by Joe Ham
Fri 10 Apr 2009 4:18
Forum: Published Studies
Topic: In Vitro vs In Vivo Research / Testing
Replies: 17
Views: 2638

Re: In Vitro vs In Vivo Research / Testing

I'm too busy to look for all the abstracts that Yvonne posted (or others) that might have 'suspicious' funding, but I'm sure they're here. Yes, but we expect better of the Grand High Pooh-Bah. ??????? I don't know of many Lymies who've ever used Pen G. So I'm confused why that's important here. Bic...
by Joe Ham
Fri 10 Apr 2009 1:15
Forum: Published Studies
Topic: In vivo activities of ceftriaxone and vancomycin
Replies: 3
Views: 1015

Re: In vivo activities of ceftriaxone and vancomycin

This 1996 paper about the dynamics of ceftriaxone and vancomycin was discussed in some detail in a thread about a year ago: http://www.lymeneteurope.org/forum/viewtopic.php?f=5&t=83&p=9890#p9890 There is a link to the full version in that post. You may remember it as the one in which you asked about...
by Joe Ham
Thu 9 Apr 2009 21:49
Forum: Published Studies
Topic: In Vitro vs In Vivo Research / Testing
Replies: 17
Views: 2638

Re: In Vitro vs In Vivo Research / Testing

Would it be impudent of me to point out that your first reference quotes of the abstract only are to a 1990 paper that was funded by Glaxo, the manufacturer of cefuroxime (Ceftin)? Or that the implications that you quoted from the abstract are not supported in the fine print of the full text?: "the ...
by Joe Ham
Thu 9 Apr 2009 19:03
Forum: Published Studies
Topic: Bartonella fatalities due to Endocarditis
Replies: 1
Views: 920

Re: Bartonella fatalities due to Endocarditis

Applied and Environmental Microbiology, October 2007 , p. 6045-6052, Vol. 73, No. 19 0099-2240/07/$08.00+0 doi:10.1128/AEM.00228-07 Copyright © 2007, American Society for Microbiology. All Rights Reserved. Mixed Infections, Cryptic Diversity, and Vector-Borne Pathogens: Evidence from Polygenis Fleas...
by Joe Ham
Thu 9 Apr 2009 17:50
Forum: Published Studies
Topic: In Vitro vs In Vivo Research / Testing
Replies: 17
Views: 2638

Re: In Vitro vs In Vivo Research / Testing

Another mention of in vitro vs in vivo discrepancies. How many of us are beating ourselves up by using an antibiotic that looks good in vitro but has minimal or no activity in vivo? However, the in vitro and the in vivo antibiotic susceptibilities of Bartonella do not correlate well for a number of ...
by Joe Ham
Tue 7 Apr 2009 20:11
Forum: General Topics
Topic: Volkman's critique of IDSA guidelines
Replies: 12
Views: 1870

Re: Volkman's critique of IDSA guidelines

If Blumenthal's action was so off the wall (unfounded) then why did IDSA settle by agreeing to review and possibly rewrite the Guidelines with fresh authors? And if it was intended by IDSA to be a rubber-stamp operation then why the extended "comment period"? http://www.lymeneteurope.org/forum/viewt...
by Joe Ham
Tue 7 Apr 2009 19:27
Forum: General Topics
Topic: IDSA Comment Period Extended to, 2009 April 24
Replies: 1
Views: 535

IDSA Comment Period Extended to, 2009 April 24

IMHO the single biggest issue with the 2006 Guidelines is IDSAs refusal to address or even acknowledge late stage relapsing (chronic) Lyme. The evidence for it is overwhelming and the mechanisms are well known; antigenic variation, intracellular location, L-forms (cysts), sequestration in poorly per...