Search found 69 matches

by Dr Googlittle
Tue 22 Jun 2010 7:56
Forum: Medical Topics
Topic: Acrodermatitis chronica atrophicans
Replies: 16
Views: 19899

Re: Acrodermatitis chronica atrophicans

Hi, The media files (figure 10 & 11) in the eMedline article about ACA (http://www.emedicine.com/derm/topic4.htm) are notheworthy, since Some people get diagnoses like Acne Rosasea instead of Borrelia. Facial ACA in inflammatory phase may cause quite painful blisters. However, facial ACA may have al...
by Dr Googlittle
Mon 14 Jun 2010 9:53
Forum: Medical Topics
Topic: Genospecie and genotype. What is the difference ?
Replies: 2
Views: 664

Re: Genospecie and genotype. What is the difference ?

One's genotype differs subtly from the genomic sequence of one's species. A sequence is an absolute measure of base composition of an individual, or a representative of a species or group; a genotype typically implies a measurement of how an individual differs or is specialized within a group of ind...
by Dr Googlittle
Sun 30 May 2010 12:01
Forum: Published Studies
Topic: Genotypic Variation and Mixtures of LB from N.America+Europe
Replies: 4
Views: 1046

Re: Genotypic Variation and Mixtures of LB from N.America+Eu

An oldie but still a bit intreresting Infect Immun. 1999 Jul;67(7):3518-24. Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans . Seinost G, Dykhuizen DE, Dattwyler RJ, Golde WT, Dunn JJ, Wang IN, Wormser GP, Schriefer ME, Luft BJ. Abstract Lyme disease begins at the...
by Dr Googlittle
Sat 29 May 2010 19:24
Forum: Published Studies
Topic: Genotypic Variation and Mixtures of LB from N.America+Europe
Replies: 4
Views: 1046

Re: Genotypic Variation and Mixtures of LB from N.America+Eu

Hi Yvonne, Thanks for the link. The notion that an increased probability that a person will be infected with more than one genotype of B. burgdorferi, potentially increases the risks of disseminated Lyme disease, was new to me. Have you seen any further references pointing to that multiple strain in...
by Dr Googlittle
Wed 28 Apr 2010 19:18
Forum: Published Studies
Topic: Lyme borreliosis: current issues in diagnosis and management
Replies: 2
Views: 636

Re: Lyme borreliosis: current issues in diagnosis and manage

Studies of patients with persistent symptoms following treatment have not shown evidence for active infection Someone's been hardcore cherry-picking if they missed all the studies documenting active infection following treatment. I believe that a distinction is made between clinical studies and ind...
by Dr Googlittle
Wed 28 Apr 2010 7:13
Forum: Published Studies
Topic: New look at "chronic Lyme", or PLS
Replies: 27
Views: 6049

Re: New look at "chronic Lyme", or PLS

Hi, Strategies to 'flush' quiescent spirochetes out of hiding may be one strategy. TNF-α blockade has proven to be quite effective for reactivating a dormant infection, both in animal models and also inadvertedly in human subjects. Sequential strategies with TNF-α blockade followed with adequate ant...
by Dr Googlittle
Wed 21 Apr 2010 23:06
Forum: Published Studies
Topic: Borreliosis mimicking lupus-like syndrome during infliximab
Replies: 7
Views: 2359

Re: Borreliosis mimicking lupus-like syndrome during inflixi

It occurred to me that this may not be the only example of a Lupus-like syndrome during anti-TNF-alpha treatment: http://scholar.google.com/scholar?start=10&q=%2Blupus+%2Binfliximab&hl=us&as_sdt=2000 Some of these examples could perhaps deserve to be reviewed in the light of recent finding regarding...
by Dr Googlittle
Wed 21 Apr 2010 20:42
Forum: Published Studies
Topic: Borreliosis mimicking lupus-like syndrome during infliximab
Replies: 7
Views: 2359

Re: Borreliosis mimicking lupus-like syndrome during inflixi

Moving from one open door to another and really old one, this time regarding peripheral neuropathy Clin Exp Immunol. 1995 Feb;99(2):196-202 . Tumour necrosis factor-alpha (TNF-alpha) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions. Khanolkar-Young S...
by Dr Googlittle
Wed 21 Apr 2010 20:20
Forum: Published Studies
Topic: Borreliosis mimicking lupus-like syndrome during infliximab
Replies: 7
Views: 2359

Re: Borreliosis mimicking lupus-like syndrome during inflixi

I may have been kicking in an alread open door with that guess: Infect Immun. 2008 Jan;76(1):56-70. Epub 2007 Oct 15. Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes. Cruz AR, Moore MW, La Vake CJ, Egger...
by Dr Googlittle
Tue 20 Apr 2010 20:49
Forum: Published Studies
Topic: Borreliosis mimicking lupus-like syndrome during infliximab
Replies: 7
Views: 2359

Re: Borreliosis mimicking lupus-like syndrome during inflixi

Perhaps the importance of TNF-α for borrelia and re-activation of latent Lyme at least in part is due to the role that the TNF-α and other players in TNF-receptor superfamily has in Autophagy: http://en.wikipedia.org/wiki/Autophagy_(cellular) Autophagy. 2007 May-Jun;3(3):245-8. Epub 2007 May 15. CD4...