Hi,FunkOdyssey wrote: Well that's quite a cliffhanger. Care to elaborate?
I thought you'd never ask. Well it turned out that after suppressing my inflammatory response with a considerable load of i.v. tetracycline derivatives, and subsequently went on to challenge my organism and my neural system im particular with i.v. Metrodinazole, I got some strange dermatologic manifestations in my face and on my left arm.
The immediate reaction from a borrelia-believer would perhaps be; "Oh, a herxheimer reaction, that's good". But these spots appeared different from impetigo etc. that you would expect from a bacterial infection. However, they were much more "spot on" to the descriptions of dematological manifestaions of herpes simplex and they also appeared neatly aligned along nerves, e.g. from my neck down to my arm and all the way to the index finger of the arm in which my neurological problems have been most pronounced.
One possible conclusion is that I may have a dissiminated HSV-1 or HSV-2 infection, which co-exists with a chronic and treatment resistent Lyme infection. However, an alternative explanation (based on the time of symtom onset and the extent of unsuccessful but 'adequate' theraphies) is that my confirmed neuroborreliosis, somehow facilitated and/or potentiated the putative HSV-infection to spread and become systemic in my peripheral nervous system.
Any which way I would like to postulate that co-infections of Lyme with pre-existent integrating DNA/RNA-viruses may be a possible cause to persistent Lyme. A dissiminated low level smoldering viral infection or possibly dissimnated"leaky viral (trans-)gene products" would (also) tend to elicit a long term Th17/Th23 axis type inflammatory immune defence with an IL-6/TNF-alpha response. This would in turn also explain why both short and long term antibiotics treatment makes me and so may others feel much heathier, irrespectably if we're getting Ceftriaxone or Doxycycline and almost independently how much of it we get.